The overarching goal of the IDDP Lab is to characterize neurobehavioral mechanisms that underlie the development and persistence of psychopathological behaviors, particularly externalizing and related behaviors (e.g., aggression, delinquency, substance use, psychopathy). Specifically, projects in our lab focus on the role of individual differences – with a specific focus on (dis)inhibitory and regulatory processes and other transdiagnostic social processes – as central mechanisms in the development of these problem behaviors. A secondary focus is on the dynamic interplay between and among these individual differences and various contextual factors that impact behavior. Our research with nonhuman primates affords the opportunity to undertake complex and innovative investigations that have clear translational value to humans.
Personality and Neuroscientific Indicators of (Dis)inhibitory and Regulatory Processes
Through this work, we aim to characterize transdiagnostic neurobehavioral mechanisms underlying externalizing and related behaviors. Current projects include, for example, examinations of differential associations between components of temperamental Disinhibition and executive functioning and various outcomes of interest (e.g., aggression, substance use, psychopathy). Additionally, we are currently working on studies examining neuroscientific and genomic correlates of psychopathology-relevant processes.
Representative recent publications:
Latzman, R. D., Palumbo, I. M., Sauvigné, K. C., Hecht, L. K., Patrick, C. J., & Lilienfeld, S. O. (2019). Psychopathy and internalizing psychopathology: A triarchic model perspective. Journal of Personality Disorders, 33, 262-287
Hecht, L. K. & Latzman, R. D. (2018). Exploring the differential associations between components of executive functioning and reactive and proactive aggression. Journal of Clinical and Experimental Neuropsychology, 40, 62-74.
Berg, J., Latzman, R. D., Bliwise, N. G., & Lilienfeld, S. O. (2015). Parsing the heterogeneity of impulsivity: A meta-analytic review of the behavioral implications of the UPPS for psychopathology. Psychological Assessment, 27, 1129-1146.
We conceptualize personality pathology within a trait personality-based framework; thus, we consider personality pathology as a configuration of traits that differ from normality in degree rather than kind. From this perspective, our research focuses on more fully understanding the neurobiological and evolutionary basis of personality in service of elucidating pathophysiological processes underlying both personality pathology and broader forms of psychopathology.
Representative recent publications:
Palumbo, I. M., & Latzman, R. D. (2019). Translational value of nonhuman primate models of antagonism (pp. 113-126). In D. R. Lynam & J. D. Miller (Eds.), The Handbook of Antagonism. San Diego, CA: Elsevier, Inc.
Lilienfeld, S. O., & Latzman, R. D. (2018). Personality disorders: Current scientific status and ongoing controversies. In J.N Butcher (Ed.), APA Handbook of Psychopathology: Psychopathology: Understanding, assessing, and treating adult mental disorders (pp. 557-606). Washington, DC: American Psychological Association.
Latzman, R. D., Patrick, C. J., Freeman, H. J., Schapiro, S. J., & Hopkins, W. D. (2017). Etiology of triarchic psychopathy dimensions in chimpanzees (Pan troglodytes). Clinical Psychological Science, 5, 341-354.
Hecht, L. K., Berg, J. M., Lilienfeld, S. O., & Latzman, R. D. (2016). Parsing the heterogeneity of psychopathy and aggression: Differential associations across dimensions and gender. Personality Disorders: Theory, Research, & Treatment, 7, 2-14.
Latzman, R. D., Drislane, L. E., Hecht, L. K., Brislin, S. J., Patrick, S. J., Lilienfeld, S. O., Freeman, H. J., Schapiro, S. J., & Hopkins, W. D. (2016). A chimpanzee (Pan troglodytes) model of triarchic psychopathy constructs: Development and initial validation. Clinical Psychological Science, 4, 50-66.
Latzman, R. D., Freeman, H. J., Schapiro, S. J., & Hopkins, W. D. (2015). The contribution of genetics and early rearing experiences to hierarchical personality dimensions in chimpanzees (Pan troglodytes). Journal of Personality and Social Psychology, 109, 889-900.
Bill Hopkins, Michale E. Keeling Center for Comparative Medicine and Research, MD Anderson Cancer Center
Scott Lilienfeld, Emory University & University of Melbourne
Chris Patrick, Florida State University
Steve Schapiro, Michale E. Keeling Center for Comparative Medicine and Research, MD Anderson Cancer Center
Chris Conway, Fordham University
Lee Anna Clark, University of Notre Dame
Jatin Vaidya, University of Iowa Hospitals & Clinics
Ahmed Megreya, Qatar University